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Organised by Dr Andreas Werner, Professor Denise Barlow and Professor Kevin Morris
Transmission of genetic information is not a top-down process but rather a dialogue between DNA and RNA. Long and short non-protein-coding RNAs have recently emerged as important mediators of the genomic readout. The input of non-protein-coding RNAs is essential to shaping transcriptional output and correlates with organismal complexity. Moreover, interruption of RNA-mediated feedback perturbs gene expression and can result in human disease.
Programme available to download here (PDF).
Biographies and audio recordings are available below.
Dr Andreas Werner, Newcastle University, UKWhat are natural antisense transcripts good for?
Professor Denise Barlow, Research Center for Molecular Medicine of the Austrian Academy of Science, AustriaMacro ncRNAs in imprinted gene clusters in the mouse and human genome
Professor Kevin Morris, The Scripps Research Institute, USADo pseudogenes function as master non-coding RNA regulators of gene expression in human cells?
Dr Piero Carninci, RIKEN Yokohama Institute, JapanThe complexity of the mammalian transcriptome
Dr Thomas Gingeras, Cold Spring Harbor Laboratory, USAImportant lessons from the transcriptomes of complex genomes
Professor John Mattick, University of Queensland, AustraliaRNA at the epicentre of development and cognition
Professor John Rinn, Harvard University, USALarge intergenic noncoding RNAs (lincRNAs): from parasites to pluripotency a panoply of functional roles
Dr Matt Wright, European Bioinformatics Institute, UKThe long and small of ncRNA gene nomenclature
Professor Claes Wahlestedt, University of Miami, USAMechanisms of discordant and concordant natural antisense regulation of gene expression
Professor Ingrid Grummt, German Cancer Research Center, Heidelberg, Germany Noncoding RNA targets chromatin modifying enzymes to regulatory gene sequences
Dr Zdravko Lorkovic, Gregor Mendel Institute of Molecular Plant Biology, AustriaRNA-directed DNA methylation in Arabidopsis
Professor David Tollervey FRS, University of Edinburgh, UKLinking RNA surveillance and genome stability
Dr Marc Bühler, Friedrich Miescher Institute for Biomedical Research, SwitzerlandEmerging roles of RNA interference in genome regulation
Professor E. Gerhart H. Wagner, Uppsala University, SwedenRegulatory RNAs in bacteria: biological roles, molecular mechanisms, protein involvement
Dr Monika Gullerova and Professor Nicholas Proudfoot FRS, University of Oxford, UKConvergent transcription and the induction of transcriptional gene silencing in eukaryotes
Dr Edith Heard, Institut Curie - Centre de Recherche Pole de Biologie du Développement et Cance, FranceThe role of non-coding RNAs in regulating X-chromosome inactivation
High-level international discussion of emerging science
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