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Scientific discussion meeting organised by Professor Henry Chapman and Professor John Spence
The recent invention of the hard X-ray laser (XFEL) has opened new vistas for structural and dynamic biology. This meeting will review the latest work, outline opportunities for future research, and describe the new techniques (snapshot SAXS, serial nanocrystallography, single-particle imaging) which take advantage of the atomic spatial resolution and femtosecond time resolution of the XFEL.
Biographies of the organisers and speakers will be available shortly and you can also download the programme (PDF). Recorded audio of the presentations will be available on this page shortly and the papers will be published in a future issue of Philosophical Transactions B.
Enquiries: Contact the events team
Dr Henry Chapman, CFEL Sxience, Germany
Biography not yet available
Dr Massimo Altarelli, European XFEL GmbH, Germany
Massimo is the Managing Director, of European XFEL GmbH, Hamburg.
His distinctions include:
Fellow, American Physical Society. Fellow, Institute of Physics (UK)“Membre d’honneur”, French Physical Society
His scientific interests electronic properties of solids, x-ray scattering and absorption in strongly correlated and magnetic systems, applications of third and fourth generation x-ray sources.
Dr Petra Fromme, Arizona State University, USA
Dr Maike Bublitz, University of Aarhus, Denmark
Dr Eaton Lattman, Hauptman-Woodward Medical, USAChair
Dr Arwen Pearson, Astbury Centre for Structural Molecular Biology, UKChair
Dr Vittal Yachandra, Lawrence Berkeley National Laboratory, USA
Vittal Yachandra received his B.Sc. and M.Sc degrees in Chemistry from Loyola College, University of Madras, and the Indian Institute of Technology at Kanpur, India. In 1975 he moved to the U.S. and received his M.S. from the University of Chicago, and his Ph.D. from Princeton University in 1982. He was a postdoctoral fellow from1982 with Melvin Klein and Kenneth Sauer at the Melvin Calvin Laboratory, Lawrence Berkeley National Laboratory, where he became a Staff Scientist in 1985. Since then his research focus has been the use of X-ray spectroscopy and EPR to study the Mn4Ca water-oxidizing catalyst in photosynthesis. His recent interests are in studying inorganic water-oxidizing catalysts in artificial photosynthetic systems, and the use of the X-ray free-electron laser to study the time-evolution of the water-oxidizing reaction in photosystem II. He is presently a Senior Scientist in the Physical Biosciences Division at the Lawrence Berkeley National Laboratory at Berkeley.
Dr Aina Cohen, SLAC SMB Crystallography, USA
Aina Cohen is a staff scientist at the SLAC National Accelerator Laboratory. Her research focuses on the development of novel techniques and specialized instrumentation for macromolecular X-ray crystallography using synchrotron radiation. Aina is group leader of the SSRL SMB crystallography development group which is responsible for the hardware and electronics used in the experimental hutches of six crystallography beam lines. She led the development of the Stanford Auto-Mounter, a robotic system for mounting crystalline samples for remote experiments, and developed the BL12-2 experimental front-end for micro-crystal / micro-beam projects at SSRL. More recently she led the implementation of a fully automated goniometer based setup for high-throughput grid-based diffraction studies of single crystals at LCLS/XPP. She earned a Ph.D. from the Department of Crystallography at the University of Pittsburgh studying the charge density distribution of small biological molecules under Professor Bryan Craven and a B.S. in ceramics engineering with a chemistry minor from SUNY Alfred.
Dr Ilme Schlichting, MPI Heidelburg, Germany
Dr Chris Tate, MRC Laboratory of Molecular Biology, UKChair
Dr Gebhard Schertler, PSI, SwitzerlandChair
Dr Janos Hajdu, Uppsala University, Sweden
Janos Hajdu is Professor of Molecular Biophysics at Uppsala University and Advisor to the Directors of the European XFEL in Hamburg. He graduated from Eötvös Lorand University in Budapest, and spent a brief postdoctoral period in Bern. He was invited by Dr. Louise N. Johnson to Oxford in 1980, and spent nearly 17 years there. He moved to Sweden in 1996. During 2006-2008, he was Professor in Photon Science at Stanford.Achievements: - The 4th dimension in X-ray crystallography, first molecular movies on chemical reactions in crystalline enzymes.- Development of Laue crystallography, first electron density maps from protein and virus crystals.- Structural characterisation of the family of mononuclear ferrous enzymes.- Elucidating the structural mechanism for the formation of penicillins and cephalosporins.- Discovery of X-ray-driven catalysis in redox enzymes.- Diffraction before destruction: Estimates on the physical limits in ultrafast imaging.- The scientific case (in imaging) for building X-ray free-electron lasers.
Dr Leonard Chavas, Deutsches Elektronen-Synchrotron, Germany
Léonard (Léo) Chavas was graduated a degree in crystallography related to Structural and Functional Biology in Japan, in the group of Prof. Soichi Wakatsuki at the Photon Factory. After getting his Ph.D., Léo obtained a Mary Curry fellowship and returned for two years in Europe, at the University of Manchester. In 2009, he went back to Japan to take the position of Assistant Professor in synchrotron radiation and crystallography, and quickly became responsible of two beamlines for structural biology at the Photon Factory. In the mean time, his interest grew for x-ray free-electron laser science, in particular with its potential for in vivo crystallography. Léo is now going to lead the construction of a beamline dedicated to Serial Femtosecond Crystallography at the European.FEL, in the group of Prof. Henry Chapman.
Dr John Spence, Arizona State University, USA
Dr Richard Neutze, University of Gothenburg, Sweden
Richard Neutze took his PhD in Physics in 1995 from the University of Canterbury (New Zealand). He was introduced to the field of molecular biophysics at Oxford University (England; group of Janos Hajdu); took a postdoc at Tübingen University (Germany); and returned to the Hajdu group in 1997, by then located at Uppsala University. In 1998 Neutze received an Assistant Professorship from the Swedish Research Council and he moved his group to Chalmers University of Technology in Gothenburg in 2000. In 2006 Neutze was appointed Professor of Biochemistry at the University of Gothenburg. Neutze has worked on the structural biology of bacterial rhodopsins; aquaporins; photosynthetic reaction centres; time-resolved Laue diffraction and time-resolved WAXS studies of membrane proteins; and helped develop new approaches to structural biology at x-ray free electron lasers.
Dr George Philips, Rice University, USAChair
Professor John Helliwell, University of Manchester, UK
Professor John R Helliwell is a research crystallographer based at Manchester University and before that he was at Daresbury Laboratory either as a University Joint Appointee or full time including as Director of Synchrotron Radiation Science. He has focused his research career on synchrotron radiation macromolecular crystallography instrumentation, methods and applications and its synergies with neutron developments especially the Laue method. He has supervised 20 PhD students many now based around the world in research posts. He has been awarded the Banerjee Medal of the Indian Institute of Science in 2000, was the Dame Kathleen Lonsdale FRS Lecturer of the British Crystallographic Association in 2011 and is the next Patterson Awardee of the American Crystallographic Association. He admires the work already done by the "X-ray lasers in biology" speakers. He has published some simple ideas for harnessing the X-ray laser in protein crystallography eg with their potential application to solving the structure of the marine coloration protein alpha-crustacyanin. He is currently Chairman of the Science Advisory committees of the ALBA Spanish Synchrotron Facility and of the Coherent X-ray Science Initiative in Melbourne and for the European Spallation neutron source in Lund is Chair of their STAP for neutron macromolecular crystallography.
Dr Seb Doniach, Stanford University, USA
Dr Rick Millane, University of Canterbury, New Zealand
Dr Millane received the Ph.D. Degree in Electrical Engineering from the University of Canterbury in New Zealand. He was on the faculty at Purdue University in the U.S. for 20 years where he worked on theoretical and computational methods for x-ray fibre diffraction analysis and its application to structural studies of polysaccharides. He is currently a Professor in the Department of Electrical and Computer Engineering at the University of Canterbury in New Zealand and was Head of Department during 2008-2011. He was awarded a two-year James Cook Research Fellowship in 2012 for work on image reconstruction in protein crystallography and using x-ray free-electron lasers. His research interests are in image reconstruction, phase retrieval, and diffraction by disordered systems, with applications in biophysical and medical imaging, and remote sensing. Dr. Millane is a Fellow of OSA and SPIE.
Dr Philip Anfinrud, Laboratory of Chemical Physics/NIDDK, National Institutes of Health, USA
Dr. Philip Anfinrud is a Senior Biomedical Research Scientist at the National Institutes of Health in Bethesda, Maryland, where he serves as Chief of the Ultrafast Biophysical Chemistry Section in the Laboratory of Chemical Physics/NIDDK. In 1990, following post-doctoral studies with Professor Robin Hochstrasser at the University of Pennsylvania, he joined the Department of Chemistry at Harvard University. A recipient of NSF and Beckman Young Investigator Awards, he developed ultrafast time-resolved IR spectroscopic methods and pursued biophysical studies of proteins. He was promoted to Associate Professor in 1995, and in 1997, was a Visiting Scientist at the European Synchrotron and Radiation Facility in Grenoble, France. In 1998, he moved to the NIH, and with his coworkers developed the methods of picosecond time-resolved Laue crystallography and picosecond time-resolved Small and Wide Angle X-ray Scattering (SAXS/WAXS). He was elected Fellow of the AAAS in 2006.
Dr Vadim Cherezov, The Scripps Research Institute, USA
Vadim Cherezov is an assistant professor at the Department of Integrative Structural and Computational Biology of The Scripps Research Institute in La Jolla, USA. He holds PhD in biophysics from the Moscow Institute of Physics and Technology. The main focus of Professor Cherezov’s group is on studies of structure and function of membrane proteins implicated in human health, with an emphasis on the role of lipid-protein interactions. For the last 15 year he participated in developments of novel tools and technologies related to applications of membrane mimetic matrix, known as lipidic cubic phase, for biophysical characterization and crystallization of membrane proteins. These developments contributed to a recent rapid progress in the structural biology G Protein-Coupled Receptors (GPCR). His current interests are in elucidation of the effects of cholesterol on function of membrane proteins, and in further development of new crystallography approaches.
Dr Elspeth Garman, University of Oxford, UKChair
Biograpjhy not yet available
Dr Keith Moffat, University of Chicago, UKChair
Keith Moffat is the Louis Block Professor of Biochemistry & Molecular Biology at the University of Chicago, where he was the Deputy Provost for Research from 2002-10. He is Senior Adviser in the Life Sciences to the Director of the Advanced Photon Source at Argonne National Laboratory, where he also heads an NIH-funded sector that serves as a national facility for time-resolved X-ray scattering applied to scientific problems in structural biology, materials science, chemistry and physics. He received his B.Sc. in physics from Edinburgh University in 1965 and his Ph.D. in biophysics from Cambridge University in 1970. While a faculty member at Cornell University from 1970-90, he developed one of the world’s first synchrotron facilities to aid structural biologists, MacCHESS. He is a member of the scientific advisory committees of the Advanced Light Source (Lawrence Berkeley Laboratory), the Linac Coherent Light Source (SLAC, Stanford University) and the Energy Recovery Linac (Cornell University); and advises the director of Lawrence Berkeley Laboratory on the Next Generation Light Source Project. His research interests focus on time-resolved X-ray crystallography, signaling photoreceptors and optogenetics.
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