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Satellite meeting organised by Dr Michaela Kendall, Professor Kevin Kendall FRS, Professor Liam Grover and Professor Paula Mendes
Bionanotechnology is advancing to control and understand bio-nano interactions. New materials and devices are developed for applications, such as medicine. Influencing biology with nanoscopic materials provides opportunity to create innovative therapies or detect disease with unprecedented sensitivity, revealing the functions of cell components or molecules. Intracellular interference implies that toxicological risk should also be considered and avoided by safe design.
Download the meeting programme
To submit a poster to the organisers for inclusion in the meeting please email a title, 150 abstract and authors to the events team. The deadline for poster submissions is Friday 28 March 2014.
Biographies of the organisers and speakers are available below. Recorded audio of the presentations will be available on this page after the event.
This is a residential conference, which allows for increased discussion and networking. It is free to attend, however participants need to cover their accommodation and catering costs if required.
Enquiries: Contact the events team
Participants are encouraged to attend the related scientific discussion meeting which immediately precedes this event and is open to all.
Professor Kevin Kendall FRS, Chemical Engineering, University of Birmingham, UK
Professor Kevin Kendall received his PhD from Cambridge and has worked for 20 years in industrial research at ICI, and also 20 years in Universities at Monash, Akron, Keele and now Birmingham. He started his research career studying friction and adhesion and became interested in the energy balance method for calculating adhesion forces. He has applied this method to many different areas including adhesive joints, composites, slurries, nanoparticles, cells and viruses. He has also been involved in the fossil energy crisis and applies fuel cells to avoid carbon emissions, especially operating a fleet of hydrogen fuel cell vehicles with a filling station on the Birmingham University campus as shown in the picture. He is now back in industry, CEO of Adelan Ltd, an SME developing several EU projects. He has written more than 300 publications and patents and was elected FRS in 1993.
Dr Michaela Kendall, University of Southampton, UKChair of Session 3 & 4
Dr Kendall is an environmental scientist, with faculty-level experience in America, Asia and Europe. She specialised in the field of airborne particles, focussing on air pollution, nanoparticle toxicity in the lung, fuel cells (a clean energy technology) and policy development for atmospheric protection. In her early career, she studied air pollution impacts on materials and human health, specialising in the exposure measurement, nano-characterisation and health impact assessment of fine particulate matter (PM2.5) and nanoparticles (<100 nm). She currently develops fuel cells to reduce combustion emissions, primarily as a public health intervention with ancillary environmental benefits. Her career goal is to curtail combustion emissions to the atmosphere, to protect human and environment health. She was awarded the prestigious Rosenblith Prize by the HEI (www.healtheffects.org) in 2004, and is a Project Manager at Adelan with a Visiting Senior Lecturer Post at University of Southampton Medical School.
Professor Liam Grover, University of Birmingham, UKChair of session 2
Professor Liam Grover’s research focuses on the interactions that occur between materials and biological systems. By enhancing our understanding of these interactions, he has been able to design implantable materials that are capable of initiating the tissue regeneration process. Prior to setting up his research group at the University of Birmingham, UK, he worked at McGill University in Montreal, where he specialised in the mechanisms known to influence the bone formation process. Professor Grover has published in excess of 100 papers, is named on five patent filings and has written four book chapters. He was one of the youngest researchers to be made a fellow of the institute of materials and was made one of the youngest professor’s in the history of the University of Birmingham at the age of 32.
Professor Paula Mendes, University of BirminghamChair of session 1
Paula M Mendes received her MSc (1997) and PhD (2002) degrees in Chemical Engineering from the Faculty of Engineering, University of Porto, Portugal. She undertook post-doctoral research ﬁrstly (2002–04) in the School of Chemistry, University of Birmingham, UK, and subsequently (2004–06) at the Department of Chemistry and Biochemistry, University of California, Los Angeles, USA. She began her academic career in the School of Chemical Engineering, University of Birmingham in 2006, as an academic fellow, and has been a Professor of Advanced Materials and Nanotechnology and EPSRC Leadership Fellow since 2013. The research in her group lies on the development of novel methods for controlling the structure and functionality of materials at the molecular and nanometer scale and their application in biology and medicine.
Professor Pascal Jonkheijm, University of Twente, NetherlandsBio-functionalization of nanoscale materials
He obtained his PhD degree with Professor Dr E W Meijer as advisor on macromolecular engineering of p-conjugated oligomers through supramolecular interactions into nanoscopic objects. His thesis was awarded with the Houwink Award on Macromolecular Organic Chemistry. After that, he moved for a post-doctoral stay as an Alexander von Humboldt research fellow to the Chemical Biology department of Professor Dr H Waldmann at the Max-Planck Institute for molecular Physiology in Dortmund (Germany). His research interests included protein microarrays and surface microstructuring techniques. From 2008 he started as an Assistant Professor in the Molecular Nanofabrication group of Professor Dr J Huskens at the University of Twente and MESA+ Institute for Nanotechnology. Recently he has been appointed there as Adjunct Professor and is heading the Laboratory of Bioinspired Engineering. He received a NWO Innovation VENI and VIDI Grant, the Young Investigator Award of the Biomedical Materials Program and a Starting ERC Grant. His group aims to develop dynamic chemical strategies to understand, direct and manipulate cellular processes with temporal and spatial control (densities, specificities, separation). Insight in the mechanisms that direct and regulate cellular functions (adhesions, migration and differentiation) will be used to make a new generation of smart biomaterials, to fabricate multifunctional biochips and to renew synthetic biology.
Dr Matthew Dalby, University of Glasgow, UKNanoscale approaches to study bio-nano-interactions
Dr Matt Dalby is a Reader in Cell Engineering in the Institute of Molecular, Cell and Systems Biology at the University of Glasgow (UoG). After completing a PhD at the IRC in Biomedical Materials in 2000 he moved to Glasgow as a PDRA on EU grant Nanomed where he wrote the first paper on cell response to all nanoscale dimensions. In 2003, he was awarded a BBSRC David Phillips Fellowship to explore stem cell mechanotransduction on nanotopography. This was followed by a lectureship in 2008 and a readership in 2010. He has published over 100 papers including on mesenchymal stem cell targeted differentiation and retention of multi potency in Nature Materials 2007 and 2011. He holds current grants from BBSRC, MRC, EPSRC and the AO foundation, has two patents and is currently trying to commercialise some of these ideas through collaboration with industry and BBSRC BRIC funding. He has won 10 awards including the Tissue and Cell Engineering Society Early Stage Investigator Award (2006), Society for Experimental Biology President’s Medal (2007) and Nexxus West of Scotland Young Bioscientist of the Year (2007). His research focusses on the cell materials interface with particular focus on nanoscale control of mesenchymal stem cells.
Dr Frankie Rawson, University of Nottingham, UKElectrochemical nano-bio-sensing of cells
Dr Rawson received a BSc (Hons) degree in Biochemistry from the University of Huddersfield in 2004. He spent 2 years working at Covance Laboratories within the Department of Molecular Genetics and Toxicology. This then led him to study for a PhD in which he developed electrochemical biosensors for detecting toxicity from 3D organo-typic liver spheroids under the supervision of Prof Hart at the University of the West of England. He then moved to New Zealand to undertake a Post-Doctoral Fellowship at the University of Canterbury under the guidance of Prof Downard within the Department of Chemistry. His research here focused on the development of conducting surfaces that could "wire" into cell membrane and cell wall redox sites. This allowed for the capture of electrons from cells and shed new light on their biological origin. This was followed by a Post-Doctoral Fellowship at the University of Birmingham within the Mendes Laboratory. Here he combined his previous skills to develop nanostructured electrodes that could electrochemically communicate with the internal environment of cells. The technology was then utilised to aid in our understanding of how an early immune cell response is elicited. Dr Rawson was then awarded an Early Career Leverhulme Fellowship in 2013 to be tenured at the University Of Nottingham within the Laboratory of Biophysics and Surface Analysis allowing Dr Rawson to make further progress in the newly emerging field of electroceutics. His research now focuses on the development of smart bio-electrochemical nanosystem for studying and controlling cellular processes on a molecular scale.
The ability to monitor cellular events in real-time is paramount to advancing fundamental biological and clinical science. Recently, pioneering nano-electrochemical technology has been utilised to electrically wire cells but there are few examples of its utilisation for sensing of chemical pathways to aid in our understanding of cellular chemistry.
With this insight in mind studies will be presented describing the development of new nanotechnology based on electrodes nanostructured with single walled carbon nanotubes (SWCNTs) and electrocatalytic films. The nanostructured sesnors were used to initially electrically “wire” non-electrogenic prokaryotic bacteria cells allowing for extracellular electrochemical communication. We were then interested in elucidating the pathways in which eukaryotic cell, namely yeast, shed electrons with the external environment. By carefully controlling the nano-topography of electrocatalytic modified surfaces we show for the first time that charge transfer events from the external surface of the cell wall of yeast could occur. Importantly, this electron transfer across the cell wall indicates that there is a need to redefine the function of the yeast cell wall.
We then utilised ITO electrodes nanostructured with SWCNTs to intracellularly “wire” macrophage cells. This cell-nanosensor construct was further modified by functionalising the SWCNTs with an electrocatalyst to enable the selective real-time monitoring of reactive oxygen species (ROS). The developed nanosensor was used to provide new insight into the early cell signalling mechanisms underpinning an immune cells response to an endotoxin. This electrochemical nanotechnology provides a generic platform that can be easily tailored, yielding new sensing tools for biologists investigating intracellular nanochemistry (Fig 1).
(1) Rawson, F J; Yeung, C L; Jackson, S K; Mendes, P M Nano Letters 2013, 13, 1.
Professor Matthias Epple, University of Duisberg-Essen, GermanyNanoparticle fabrication for therapeutic delivery
Matthias Epple obtained his PhD in Physical Chemistry in 1992 at the University of Braunschweig, spent one year as Postdoctoral Fellow at the University of Washington in Seattle and then went to the University of Hamburg. In 2000, he became Associate Professor at the University of Bochum, and in 2003 he became Full Professor of Inorganic Chemistry at the University of Duisburg-Essen. His research interests comprise synthesis and characterization of biomaterials and nanoparticles and the understanding of the fundamental processes of biomineralization. He is a Fellow of the Royal Society of Chemistry.
Professor Pamela Habibovic, University of Twente, NetherlandsEngineering instructive biomaterials for tissue regeneration: a matter of right tools
Pamela Habibovic, BEng (Hons.) PhD, Associate Professor (tenured), University of Twente, MIRA Institute for Biomedical Technology and Technical Medicine, Department of Tissue Regeneration, Enschede, the Netherlands
Dr. Pamela Habibovic (1977, Tuzla, Bosnia-Herzegovina) obtained her PhD degree in 2005 from the University of Twente in the Netherlands. In 2006, she worked as post-doctoral research fellow at Children’s Hospital Boston-Harvard Medical School and in 2007 she spent a year as post-doctoral research fellow at McGill University in Montreal, Canada. She is currently a tenure track associate professor at the University of Twente, where she leads a research group with five PhD students, one post-doctoral fellow and a number of Master and Bachelor students. The main focus of her research group is on synthetic bone graft substitutes, bioinorganics and high-throughput approaches in biomaterials research. For her research she received prestigious Veni and Aspasia grants of the Netherlands Organisation for Scientific Research among other external research funds. She was elected a council member of the European Society for Biomaterials, she is board member of the Female Faculty Network Twente and serves as an editorial board member of the journal Biomatter. In 2013, she received the Jean Leray Award of the European Society for Biomaterials
Dr Jeff Karp, Brigham and Women's Hospital - Harvard Medical School, USATowards bioengineered control of cell fate post transplantation
Jeff Karp is an Associate Professor at Harvard Medical School, Brigham and Women's Hospital. He is Principal Faculty at the Harvard Stem Cell Institute. His research uses materials and biology to solve medical problems with emphasis on nanoscale/microscale materials and bioinspired biology. He has published more than 80 peer-reviewed papers and book chapters and has given over 100 national and international invited lectures and has 30 issued or pending patents. In 2011 the Boston Business Journal recognized Dr Karp as a Champion in Healthcare Innovation. MIT’s Technology Review Magazine (TR35) also recognized Dr Karp as being one of the top innovators in the world under the age of 35. He received the 2011 Society for Biomaterials Young Investigator Award and his work has been selected as one of Popular Mechanic's "Top 20 New Biotech Breakthroughs that Will Change Medicine”. Dr Karp was also elected in 2013 to the American Institute for Medical and Biological Engineering's College of Fellows. Dr Karp is also an acclaimed mentor. He was selected as the Outstanding Faculty Undergraduate Mentor among all Faculty at MIT in 2008 and received the 2010 HST McMahon Mentoring award for being the top mentor among all faculty who mentor Harvard-MIT students. To date, 12 postdocs from his laboratory have secured faculty positions at institutions throughout the world.
Control of cell fate and its extracellular environment is critical for tissue regeneration and cell therapy. This talk will explore methods to enhance the engraftment of systemically infused stem cells through engineering the cell surface to induce a robust rolling response. This approach is based on leukocytes ability to target tissues via specific interactions with the vascular endothelium. In addition, a strategy to engineer cells with an intracellular depot of phenotype altering agents will be described that can be used for drug delivery or programming cell fate via both intracrine-, paracrine-, and endocrine-like mechanisms. The talk will also examine the potential of cell surface sensors that can be used to detect signals within the cellular nano-environment with unprecedented spatial and temporal resolution. This should be useful for monitoring the cell secretome following transplantation, for drug discovery and for elucidating niche biology in vivo.
Professor Howard Clark, University of Southampton, UKNanoparticles entering the human lung
Professor Clark read medicine at Cambridge and completed clinical training at Addenbrooke’s hospital in Cambridge. He also gained a degree in Philosophy. After general paediatric training in Bristol and London, he took up a Fellowship in Neonatal-Perinatal Medicine at the University of California, San Francisco (UCSF). In addition to training in neonatology he carried out basic research on lung surfactant biochemistry and metabolism for which he was awarded the MD by Cambridge University. On returning to Britain he carried out basic research on lung surfactant proteins A and D at the University of Oxford for which he was awarded the DPhil. A Fellowship for Medical Research to continue these studies in Oxford followed. Thereafter Prof Clark was awarded a Senior Research Fellowship in Medicine in 2004 and he left Oxford to take up his current position as Head of the Department of Child Health at Southampton in 2007.
Dr Jonathan Powell, MRC HNR, UK Nanoparticle handling by the human intestinal tract: physiological, pharmacological and toxicological implications
Professor Andre Nel, UC Center for the Environmental Impact of Nanotechnology, USA
Biography not yet available
Dr Steffi Friedrichs, Nanotechnology Industries Association, UKNanosafety by design
Professor Andrew Maynard, Risk Science Center, University of Michigan, USABalancing potential benefits and impacts of nanoscale materials
Andrew Maynard is the NSF International Chair of Environmental Health Sciences at the University of Michigan School of Public Health. He is Chair of the Environmental Health Sciences department at the University of Michigan, and Director of the University of Michigan Risk Science Center. Maynard is a leading expert on the responsible development and use of emerging technologies, and on innovative approaches to addressing emergent risks. His academic and professional work primarily addresses the potential health, environmental and social impacts and benefits of technology innovation, using integrated approaches to explore effective solutions to emerging challenges. He has testified before congressional committees on a number of occasions, has served on National Academy panels and is a member of the World Economic Forum Global Agenda Council on Emerging Technologies. Maynard teaches graduate courses on risk assessment, science communication, environmental health policy, professional development and entrepreneurial ethics, and lectures widely on technology innovation and responsible development. In addition to his publications in the academic literature, Maynard is also a well-known communicator of science to non-expert audiences, and is active in exploring ways of using emerging media to connect with new audiences.
Tanja E J Kleinsorge, Parliamentary Assembly of the Council of EuropeNanotechnology: balancing benefits and risks
Tanja E J Kleinsorge, née Klein, was born in Münster, West Germany. She studied Slavic Studies, History, Political Science and Law at the Westfälische-Wilhelms-Universität Münster from 1988 to 1991. She continued her studies with a merit scholarship at Georgetown University, Washington DC, and graduated with a degree as a Master of Science in Foreign Service in May 1993 with the Dean’s Award for Academic Excellence and a Certificate in Russian Area Studies. She started her career with the Council of Europe in August 1993, working for the Parliamentary Assembly, first in the Secretariat of the Political Affairs Committee, then in the Secretariat of the Committee on Legal Affairs and Human Rights. She has since gained an additional Master of Arts degree in History, Law and Political Science from the FernUniversität Hagen in Germany by correspondence. She then served as the Head of the Secretariat of the Committee on Equal Opportunities for Women and Men for seven years, before being called upon to head the Committee on Social Affairs, Health and Sustainable Development, a post she still holds.
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