Repairing the code

The 2011 Francis Crick Lecture is given by Dr Simon Boulton from Cancer Research UK for his exceptional achievements in the field of DNA repair.

DNA, also known as the 'blue print' of life, encodes the instructions for the development and function of the vast majority of organisms on our planet. Despite its importance, DNA is intrinsically unstable and is prone to breakage and chemical modifications. If left unrepaired DNA damage can giving rise to mutations, which alter the coding sequence. To counteract the deleterious effects of DNA damage, cells have evolved specialized DNA repair mechanisms. Insights into DNA repair processes and their control has firmly established the importance of DNA repair in ageing and cancer.

This talk discusses the damage that can occur to DNA, and the processes which can be used to repair DNA following damage. Dr Boulton discusses the links between DNA repair and ageing and cancer.

Dr Simon Boulton is Senior Research Scientist and group leader of the DNA Damage Response (DDR) Laboratory at Cancer Research UK, London Research Institute, Clare Hall Laboratories and an honorary Professor at University College London. He is a leader in the fields of DNA repair, DNA damage checkpoint signalling and meiosis. Dr Boulton’s lab currently exploits the respective experimental strengths of C. elegans, cultured mammalian cells, mouse models and biochemistry to investigate the DDR. This combination of approaches has led them to make a number of seminal contributions to the field of genome instability and cancer. The current and long-term goals of his lab are to understand how DNA repair processes are regulated in mitotic and meiotic cells.

The Francis Crick Lecture is given annually in any field in the biological sciences. Preference is given to genetics, molecular biology and neurobiology, the general areas in which Francis Crick worked, and to fundamental theoretical work, which was the hallmark of Crick’s science.

The lectureship was endowed by Sydney Brenner FRS in memory of Francis Crick FRS. The first lecture was given in 2003.

Repairing the code 6-9 Carlton House Terrace London SW1Y 5AG UK

Events coming up

  • The next big thing 29 May 2015 at Hay Festival, Hay-on-Wye, Wales Four Royal Society Research Fellows discuss their work at the forefront of science at the Hay Festival.
  • Stuff matters 31 May 2015 at Hay Festival, Hay-on-Wye, Wales Join award winning author Mark Miodownik at the Hay Festival.
  • Elements, genomes and ecosystems: cascading nitrogen and phosphorus impacts across levels of biological organisation 01 June 2015 at The Royal Society at Chicheley Hall, home of the Kavli Royal Society International Centre, Buckinghamshire Theo Murphy international scientific meeting organised by Professor Andrew Leitch, Professor Maurine Neiman, Professor Dag Hessen, Professor Puni Jeyasingh, Professor Lawrence J. Weider and Dr Ilia Leitch

For more events please see the events diary.