Professor Carol Prives FRS
Carol Prives was educated in Canada, receiving her BSc and PhD from McGill University and received postdoctoral training at Albert Einstein College of Medicine and the Weizmann Institute where she became a faculty member. She then joined the Biological Sciences Department at Columbia University where she was named the DaCosta Professor of Biology in 1995 and served as Chair of that department between 2000 and 2004.
Since the late 1980’s her work has focused on the p53 tumor suppressor protein, the product of the most frequently mutated gene in human cancers. She and her group have elucidated aspects of the structure and function of the p53 protein especially as it relates to its roles as a transcriptional activator. In parallel, her group has examined how cancer related mutant forms of p53 regulate tumorigenesis. Work from her laboratory has also illuminated the functions of the key p53 negative regulators, Mdm2 and MdmX.
Dr Prives has served on numerous advisory boards and is also a member of the Editorial Boards of Cell, Genes & Development, Cancer Discovery .
Proceedings of the National Academy of Sciences.
DaCosta Professor of Biology, Department of Biological Sciences, Columbia University