Alan Lehmann is a molecular geneticist whose research has helped to show how cells are able to repair damaged DNA, and how these repair processes can go wrong in patients with certain genetic disorders. His work has furthered our understanding of the links between DNA repair and cancer.
He identified a faulty gene that is responsible for the skin condition xeroderma pigmentosum (XP), which causes extreme sensitivity to sunlight and a strong predisposition to skin cancer. He subsequently showed how mutations in the same gene can cause two other conditions that are clinically very different from XP.
Alan has developed diagnostic tests for XP and his laboratory runs a worldwide diagnostic service for XP, as well as Cockayne Syndrome and Trichothiodystrophy — other conditions resulting from mutations in the same or related genes. His XP diagnostic service is an integral part of the national XP multidisciplinary clinic. He is a Fellow of both the Academy of Medical Sciences and the Society of Biology.
- Research Professor, MRC Genome Damage and Stability Centre, University of Sussex
- Biochemistry and molecular cell biology
Biochemistry and molecular biology