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Research Fellows Directory

Benjamin G Hale

Dr Benjamin G Hale

Research Fellow

Organisation

University of Glasgow

Research summary

In order to propagate, influenza viruses must enter the cells of an individual host and convert them into efficient virus-producing factories. Unlike humans, influenza viruses possess very few genes, thus they are highly dependent upon the cell's own molecular machinery after entry. Previous studies have identified many of the human genes (and the functional proteins they encode) that are needed for influenza virus replication. However, how precisely many of these required host factors assist vi rus propagation is unclear. I am interested in a group of host proteins called E3 ligases that act as key regulators of the cell's internal protein machinery. E3 ligases can change the function or lifespan of other host proteins by marking them with various ubiquitin-like tags, which basically act as molecular 'switches'. In my work, I want to find out which of these host E3 ligases support influenza virus replication, which cellular proteins they mark with ubiquitin-like tags, and how these ubi quitin-like tags chang

Interests and expertise (Subject groups)

Grants awarded

Interplay between influenza viruses and host ubiquitin signalling.

Scheme: Sir Henry Dale Fellowship

Dates: Jan 2013 - Jan 2018

Value: £898,991