Research Fellows Directory
Mr Bhanu Singh
University of Edinburgh
Organized and regulated self-assembly of proteins is fundamental to many biological processes, so it is important for our well being. However under certain condition self-assembly of some proteins and polypeptides leads to the formation of supramolecular structures, which is responsible for many diseases e. g. Alzheimer and Parkinson’s disease.
Nucleation is a primary and essential event in protein self-assembly phenomena. Therefore knowledge of kinetics of nucleation is important. A multitude of study in this direction has enriched our knowledge on nucleation and self-assembly of proteins. Theoretical modelling and experimental studies have shown macromolecular crowding and spatial confinement plays important role in protein self-assembly. However, no study has been reported on the combined effect of both these factors on protein self-assembly. Present study is aimed to work with an amyloidogenic protein, alpha-synuclein under crowded and confined condition to study early stage kinetics of nucleation that mimic the in vivo condition more closely. Also, knowledge obtained from such study can provide newer methods for generation of protein nanoparticles for a variety of applications.
Interests and expertise (Subject groups)