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Research Fellows Directory

Bing Song

Professor Bing Song

Research Fellow

Organisation

Cardiff University

Research summary

Millions of people worldwide suffer from central nervous system injury, leading to subsequent poor quality of lives. The treatment of brain and spinal cord injury (SCI) is extremely difficult, due to the limited capacity of brain / spinal cord to self-renew themselves. Stem cells replacement has huge potential in treating SCI or brain injury, we propose to investigate the control mechanisms of cell division / migration of the neural stem cells, in order to optimise their potential in stem cell replacement therapy. This is a highly challenging and rewarding project using unconventional approaches of multi-disciplinary studies combining electric signalling and nanotechnology, to investigate the molecular and genetic control mechanisms of neural stem cell division and migration. This project will have extraordinary impact into both basic scientific research of neural stem cell division and migration control, and potential clinical treatments using stem cells replacement therapies for neurodegenerative diseases. This project will fully reveal the role of electric signals in regulating division and migration of neural stem cells in both 2D and 3D cultures, and dissect the division / migration behaviours of transplanted neural stem cells in several wound models. It will provide extensive information on molecular and genetic mechanisms of electric signals controlled division / migration of stem cells, and the potential interactions between electric signals and chemical guidance cues. This project will establish the ground rules of electrical-based therapies in treating devastating central nervous system injury, and bring an exciting new tool to the clinical treatment for neurodegenerative diseases using a combination of nanotechnology and electric signals, and neural stem cells replacement therapies.

Interests and expertise (Subject groups)

Grants awarded

Controlling Neural Stem Cells Division Electrically

Scheme: University Research Fellowship

Dates: Oct 2010 - Sep 2014

Value: £308,972.67

Controlling neuronal stem cell division electrically

Scheme: University Research Fellowship

Dates: Oct 2005 - Sep 2010

Value: £274,153.01

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