Professor Tony Kouzarides FMedSci FRS
Royal Society Napier Professor, The Gurdon Institute, University of Cambridge
Tony Kouzarides is world leader in the field of chromatin modification and its roles in transcriptional control and cancer. His finding in 1996 that the transcriptional co-activator CBP is a histone acetyltransferase was one of the key discoveries that started the modern era of chromatin research. His subsequent work has identified several new histone modifications, described their functions in transcription and DNA repair and has highlighted their mis-regulation in cancer. His demonstration that a histone acetylation pathway inhibitor is an effective treatment for MLL-leukaemias in disease models has opened the way to its use in clinical trials.