Professor Randy Read FRS
Wellcome Trust Principal Research Fellow, Professor of Protein Crystallography, Cambridge Institute for Medical Research, University of Cambridge
Professor Read is known internationally for his outstanding and fundamental contributions to the development of macromolecular crystallographic software. His application of maximum likelihood based algorithms to the solution of macromolecular crystal structures by molecular replacement (a technique that uses a known structure of a homologue to solve an unknown structure) has resulted in software (Phaser) that is foremost in the field. He also devised and demonstrated an improved likelihood target function for model refinement that has been adopted by all major refinement programs. In addition, Professor Read has led structural work that has made significant contributions to understanding the mechanisms of proteins relevant to disease (bacterial toxins and serpins).
Likelihood in crystallography: known knowns and known unknowns (MP3)