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Gary Mirams

Dr Gary Mirams

Dr Gary Mirams

Research Fellow

Interests and expertise (Subject groups)

Grants awarded

Improving assessment of drug-induced cardiac risk with mathematical electrophysiology models.

Scheme: Sir Henry Dale Fellowship

Organisation: University of Oxford

Dates: Feb 2014-Feb 2019

Value: £534,961

Summary: The leading cause of withdrawal of pharmaceutical drugs from the market is a disturbance to the hearts rhythm, which can be fatal. The reason drugs can cause side effects on the heart is that the heart's activity depends on the flow of electrically charged particles - known as ions - in and out of heart muscle cells through channels made of proteins. These 'ion channels' can be blocked by pharmaceutical drugs, and this can cause unwanted disturbances to the heart's rhythm. Recent innovations in cell line technologies mean that pharmaceutical companies can now detect to what extent a drug blocks an ion channel as a matter of routine. By repeating these experiments, for many different ion channels, we can screen all of the susceptible ion channels in the heart. I will use data from these ion channel screens to feed into mathematical models for the electrical activity of the heart, and predict the effect of drugs on heart cells and the whole heart. By using human-specific mathematical models we aim to improve

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