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Research Fellows Directory

Honglei Liu

Miss Honglei Liu

Research Fellow

Organisation

University of St Andrews

Research summary

Cyclic compounds are widely presented in natural products and synthetic pharmaceuticals. Annulation reaction is a powerful tool for synthesis of cycles from starting materials under mild condition. My research interest is focused on the development of new annulation reactions. Through using zwitterion as reactive intermediate, I studied metal-catalyzed cycloaddition reactions of reactive dipolar species with stable 1,3-dipoles and Lewis base-catalyzed cycloaddition reactions of reactive dipolar species with stable 1,3-dipoles. In addition, with the use of chiral organocatalyst or metal catalyst, asymmetric cycloaddition reactions have been explored to efficiently synthetize cyclic compounds containing multi chiral centers with good enantioselectivity and diastereoselectivity.

Interests and expertise (Subject groups)

Grants awarded

Dynamic Kinetic Resolution/Desymmetrisation of Atropisomeric Biaryl Diols Using Isothioureas

Scheme: Newton International Fellowships

Dates: Feb 2018 - Jan 2020

Value: £99,000