Research Fellows Directory
Jorge Lopez Tello
Dr Jorge Lopez Tello
University of Cambridge
During pregnancy, the mother must adapt metabolically to support offspring growth. Failures in maternal adaptation can result in pregnancy complications like gestational diabetes, which is a risk factor for type-2 diabetes in later motherhood. The placenta secretes hormones with metabolic effects, although the precise role of placental endocrine function in determining maternal metabolic health is largely unknown. During this fellowship, I will use conditional over-expression of the growth gene, Igf2 in endocrine cells of the mouse placenta to increase placental hormone production and determine impacts on maternal metabolism during pregnancy and after delivery using metabolic tests and scanning. I will also identify the epigenetic mechanisms by which the mother is prone to metabolic dysfunction due to placental endocrine malfunction using RNAseq and sequenome analyses of maternal tissues. These studies are important for understanding the development of metabolic diseases during and after pregnancy.
Interests and expertise (Subject groups)