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Research Fellows Directory

Keertan Dheda

Professor Keertan Dheda

Research Fellow

Organisation

London School of Hygiene and Tropical Medicine

Research summary

Keertan Dheda is currently Professor of Medicine at the University of Cape Town, where he heads up the Division of Pulmonary Medicine. He also holds a Visiting Professor appointment at UCL. His broad research interests include the diagnosis, management, and immunology of tuberculosis with an emphasis on the study of drug-resistant TB and its pathogenesis. More recently his laboratory has become interested in the relationship between next generation whole genome sequencing of TB isolates and transcriptomic studies using RNAseq, to better understand the relationships between mycobacterial factors and their associations including drug-specific mutations, outcomes, transmission dynamics including identification of super-spreaders, and drug penetration into pulmonary compartments. The current project is in collaboration with Dr Taane Clark at the LSTMH to evaluate the relationship between phenotypic and genotypic susceptibility tests, and the relationship between mycobacterial mutations and clinical outcomes in patients with highly drug-resistant TB. Related work will evaluate the potential clinical impact of new diagnostic technologies such as whole genome sequencing on patient-related outcomes.

Interests and expertise (Subject groups)

Grants awarded

Using whole genome sequencing to identify genetic features of Mycobacterium tuberculosis that correlate with drug susceptibility and clinical outcome in a prospective study of patients with XDR-TB.

Scheme: Newton Advanced Fellowship

Dates: Mar 2015 - Feb 2018

Value: £105,000

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