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Research Fellows Directory

Marilia Buzalaf

Professor Marilia Buzalaf

Research Fellow

Organisation

University of Cambridge

Research summary

Dental erosion is the loss of tooth substance caused by dietary or gastric acids. An increased prevalence of dental erosion has been reported worldwide in the last decades, which has been attributed mainly to the high consumption of acidic foods and drinks. Thus, our group has devoted considerable attention to develop preventive measures against dental erosion. We have attempted to modify acidic beverages, by the addition of ions such as calcium, fluoride and iron. We have also investigated the role of fluoridated dentifrices in the prevention of dental erosion. It has been shown that patients at risk for dental erosion can benefit from the use of fluoridated dentifrices, but there is no additional benefit if high-fluoride dentifrices are used. We have also demonstrated that the stimulation of the salivary flow by chewing-gum can be a good strategy to prevent erosion. New preventive products have also been developed by our group. A very promising one is the titanium tetrafluoride varnish, which was shown to have a good effect for the prevention of erosion in in vitro and in situ studies and is currently being evaluated in a clinical trial. We were the first group to show that the preservation of the demineralized organic matrix by the use of matrix metalloproteinase inhibitors, especially if delivered in the form of gels, considerably reduces the progression of dentine erosion. Recently we have focused attention in modifying the acquired pellicle to increase its preventive potential against erosion.

Interests and expertise (Subject groups)

Grants awarded

Identification of proteins conferring protection against dental erosion

Scheme: Newton Advanced Fellowship

Dates: Mar 2015 - Feb 2018

Value: £74,000

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