Mark Lemmon is the David A. Sackler Professor of Pharmacology at the Yale University School of Medicine, and Co-Director of the Yale Cancer Biology Institute. His research combines biochemistry and structural biology with cell biology, focusing on understanding molecular mechanisms of transmembrane signaling by cell-surface growth factor receptors such as the epidermal growth factor (EGF) receptor.
Mark has made important contributions to the discovery of both normal and pathological activation mechanisms of growth factor receptors and the signaling networks that they engage within cells. He is also committed to exploiting this understanding clinically. These receptors and their downstream effectors are activated aberrantly in numerous cancers, and are important targets of cancer drugs. Mark’s recent work has focused on the need to understand the biochemistry of oncogenic activation to use such drugs effectively.
Before moving to Yale, Dr. Lemmon was George W. Raiziss Professor and Chair of Biochemistry and Biophysics at the University of Pennsylvania Perelman School of Medicine. He received his bachelor’s degree in Biochemistry from Hertford College, Oxford, and his Ph.D. from Yale University.
David A Sackler Professor of Pharmacology, Department of Pharmacology, Yale University
Co-Director, Cancer Biology Institute
Interest and expertise
- Astronomy and physics
- Biochemistry and molecular cell biology
- Biochemistry and molecular biology, Biophysics and structural biology, Cell biology (incl molecular cell biology)
- Health and human sciences
Cancer, Cell signaling, Enzymology, Growth control, Lipids, Membranes, Molecular biophysics, Molecular recognition, Oncogenes, Oncology, Personalized medicine, Phospholipids, Phosphorylation, Protein folding, Protein modification, Protein structure, Receptors, Signaling networks, Targeted inhibitors, Transformation