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Research Fellows Directory

Nicholas Turner

Professor Nicholas Turner

Research Fellow


University of Manchester

Research summary

Biocatalysis is increasingly being used as a green technology for the manufacture of the chemicals of the future, including pharmaceuticals, agrochemicals, nutraceuticals, polymers, flavours & fragrances and materials. In order for natural enzymes to be suitable for practical application they need to be engineered such that they possess the characteristics, e.g. stability, selectivity, substrate tolerance, that enable them to be used on large scale in industry. Enzymes can be engineered by both rationale and directed evolution methods in order to create variants with improved properties compared to the wild-type versions. At the University of Manchester we have developed a number of technologies for directed evolution which allow a broad range of biocatalysts to be improved in this way. By combining random mutagenesis with high-throughput screening it is possible to create large protein libraries and then identify improved variants for subsequent development and application on a preparative scale

Interests and expertise (Subject groups)

Grants awarded

New Biocatalysts by Design and Evolution

Scheme: Wolfson Research Merit Awards

Dates: Jan 2012 - Dec 2016

Value: £52,500