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Omer Dushek

Dr Omer Dushek

Dr Omer Dushek

Research Fellow

Interests and expertise (Subject groups)

Grants awarded

Predicting efficient T cell activation with therapeutic applications.

Scheme: Sir Henry Dale Fellowship

Organisation: University of Oxford

Dates: Sep 2012-Sep 2017

Value: £678,343

Summary: T cells are white blood cells that continuously patrol the body in search of evidence of infection or cancer and they recognize these agents when receptors on their surface directly bind to fragments or 'antigens' derived from infectious organisms or cancer cells. The process of antigen recognition has been extensively studied in the hope that this knowledge can be exploited for the development of therapies that re-direct T cells to kill infected or cancerous cells. Immunologists have characteri zed the proteins involved in antigen recognition but because they interact in complicated ways it is difficult to predict how manipulating specific proteins will alter antigen recognition. This is an example of a complex system, such as transportation networks, ecosystems or computers, whereby changing one component often alters the whole system in unpredictable ways. My proposed research aims to build mathematical models that capture the complex protein interaction network that immunologists ha ve established. These

Investigating signal initiation in T cell receptor clusters

Scheme: Newton International Fellowships

Organisation: University of Oxford

Dates: Aug 2009-Aug 2011

Value: £101,000


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