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Patricia Muller

Dr Patricia Muller

Dr Patricia Muller

Research Fellow

Interests and expertise (Subject groups)

Grants awarded

Mutant p53 enhances receptor recycling to enhance invasion and chemo-resistance.

Scheme: Sir Henry Dale Fellowship

Organisation: University of Leicester

Dates: Aug 2013-Aug 2018

Value: £831,980

Summary: Cancers often arise from alterations in a large variety of proteins that make cancer cells grow uncontrollably. One of the proteins that is very frequently altered in several different cancers is p53. Normally p53 protects against the formation of tumours by turning on several processes that stop cells from growing. An altered p53 protein can no longer fulfil these protective functions and, more importantly, obtains other functions that make cancer cells disseminate through the body and make the m resistant to chemotherapy. Only recently have we started to understand a little bit more on how mutant p53 obtains these other functions and how these lead to metastasis. With the proposed work I want to understand these processes better and I will investigate whether similar cellular processes that are activated by mutant p53 to disseminate can also be involved in the resistance to chemotherapy. An increased knowledge of these processes can in the longer term lead to better therapies to targe t cancers with mutatio

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