Scheme: University Research Fellowship
Organisation: University College London
Dates: Feb 2015-Jan 2020
Summary: My current research focusses on using multimodal X-ray imaging (phase, absorption and scattering) to obtain additional information with which to solve the inverse problem of photoacoustic tomography. Solving this problem will enable much more sensitive and accurate functional imaging in medical and biomedical applications.
X-ray imaging has traditionally been used to acquire images of X-ray absorption within a sample. Over, approximately, the last two decades, methods of imaging the refraction and multiple scattering of X-rays have been developed. I will employ the method developed by UCL’s Prof. Alessandro Olivo to develop methods of estimating acoustic and optical properties of biological tissue from multimodal X-ray images.
When used in a computed tomography mode, multimodal X-ray imaging can be used to obtain three dimensional estimations of sample’s acoustic and optical properties. This information can then be used to inform the inverse problem of optical coherence tomography.
The inverse problem of optical coherence tomography is the problem of calculating, for example, the concentration of a particular chromophore, which may be in the presence of others, within a sample. This allows quantitative, functional imaging to be performed. This is a particularly challenging inverse problem as it requires that the acoustic and optical properties of a sample be estimated as part of the solution.
By estimating this information using X-ray imaging, the solution can be made more accurate, robust and more importantly, tractable.