Peter Sadler was one of the first researchers to investigate the chemistry of metals in medicine. Since the 1970s, he has proposed, developed and tested many metal-based drugs, some of which form the core of cancer-fighting drugs commonly used in chemotherapy. Peter has also contributed to treatments for arthritis and reagents for MRI imaging of the body.
He focused his early research on an injectable, gold-containing drug for arthritis, which led to an industrial collaboration to apply such medicines to cancer. He also made significant contributions to platinum-based anticancer drugs, including their synthesis, and subsequently used NMR techniques to examine their mode of action.
More recently, Peter has developed platinum and ruthenium drugs that can be activated — upon exposure to a pulse of light — to precisely target cancers. This has enabled a reduction in their side-effects. He is also interested in catalytic organometallic drugs that can be administered in low doses and destroy cancer cells by new mechanisms involving redox modulation, thus exploiting the defects in the power houses (mitochondria) of cancer cells.
Professor of Chemistry, Department Of Chemistry, University of Warwick
Mok Hing Yiu Distinguished Visiting Professor in Chemistry, University Of Hong Kong, Department of Civil Engineering
Interests and expertise
Metal coordination chemistry,
Metals in medicine