Skip to content
Fellows Directory

Philippa Marrack

Philippa Marrack

Dr Philippa Marrack FMedSci FRS

Fellow


Elected: 1997

Biography

Philippa Marrack is an immunologist who studies the life, death and function of the immune system’s T cells. Her work has application in both the treatment of autoimmune disorders and in the development of enhanced vaccines, which work by inducing T- and B-cell memories to protect from future infection.

Amongst her research highlights has been the discovery that autoresponsive developing T cells are terminated in the thymus, thereby ensuring that T cells are tolerant of the body’s own tissues. She was first to identify superantigens, a product of disease-causing microbes that can lead to the problematic, large-scale activation of T cells. IN addition, Philippa revealed that helper T cells identify antigens in combination with major histocompatibility complex proteins.

She has won numerous awards in recognition of her work, including a Lifetime Achievement Award from the American Association of Immunologists in 2003 and the Wolf Prize in Medicine in 2015. Philippa belongs to a number of other prestigious scientific societies, including the Academy of Medical Sciences and the US National Academy of Sciences.

Interest and expertise

Subject groups

  • Microbiology, immunology and developmental biology
    • Cellular and humoral immunology

Awards

  • Royal Society GlaxoSmithKline Prize and Lecture

    In recognition of their seminal contributions to T-cell biology, which include the characterisation of the T-cell receptor; the demonstration that self-tolerance is caused by clonal elimination in the thymus; and the discovery that bacterial toxins act as 'superantigens'.

Was this page useful?
Thank you for your feedback
Thank you for your feedback. Please help us improve this page by taking our short survey.