Dr Phillip Hawkins FRS
Phillip Hawkins is a molecular biologist who has made many contributions to our understanding of the role of certain enzymes within cells. Specifically, Phillip works on enzymes called PI 3-kinases (PI3Ks), which play a role in the signalling pathways that allow cell surface receptors for hormones and growth factors to control important intracellular events.
He identified the main substance that PI3Ks act on in cells and revealed some of the molecular details that explain how PI3K-mediated signalling pathways are crucial in regulating cell growth and movement.
Phillip now focuses on the role of PI3Ks in neutrophils, cells that are important for generating immunity and the body’s inflammatory response. His recent work has elucidated how PI3Ks regulate the ability of neutrophils to home in on sites of infection and inflammation and destroy pathogens. His significant work has the potential to help develop new treatments for cancers and diseases involving chronic inflammation.
Interest and expertise
- Biochemistry and molecular cell biology
- Cell biology (incl molecular cell biology)
AKT signaling cascade, Polyphosphoinositide signaling cascade, PI3K, Intracellular signalling, neutrophils, PIP3, NADPH oxidase, Chemotaxis