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Research Fellows Directory

Randolph Noelle

Professor Randolph Noelle

Research Fellow


King's College London

Research summary

We have identified a molecule (VISTA) that inhibits immunity. As such, if you block this molecule, immunity improves and one can make immune responses that can attack a cancer and kill it. We have also produced this molecule (VISTA) in the lab. If you administer this molecule, it will suppress immunity. There are many indications where you want to suppress immunity. In the first case, multiple sclerosis (MS) is an autoimmune disease where your immune system attacks your central nervous system. In models of MS, the administration of VISTA can suppress the development of disease. We are working now with the pharmaceutical industry to develop VISTA as a drug to treat autoimmune indications in humans. Such indications will be MS, lupus and rheumatoid arthritis.

Grants awarded

Vitamin A regulates immunity and tolerance

Scheme: Wolfson Research Merit Awards

Dates: Sep 2009 - Aug 2014

Value: £50,000