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Research Fellows Directory

Rhona Borts

Professor Rhona Borts

Research Fellow

Organisation

University of Leicester

Research summary

During sexual reproduction specialised cells divide by a process called meiosis to make gametes. By the end of meiosis the genetic material, which is stored in chromosomes, must be halved so that when two gametes fuse the new offspring has a normal quantity of genetic material. When this fails infertility may result. The ability to halve the genetic content of cells is dependent on the creation of programmed (self-inflicted) DNA damage. Repair of this damage is used by the dividing cells to link chromosomes together in a way that helps with sharing them out later. The repair of this break also creates genetic diversity essential for natural selection.. By studying in detail these intermediate steps in the repair pathway, as well as the exact sequence of the repaired DNA, we are aiming determine how certain genes influence the damage repair to be useful to the meiotic cell.

Grants awarded

Genetic and Environmental Control of Crossing Over in Saccharomyces cerevisiae

Scheme: Wolfson Research Merit Awards

Dates: May 2007 - Apr 2012

Value: £62,500

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