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Fellows Directory

Richard Perham

Richard Perham

Professor Richard Perham FMedSci FRS


Elected: 1984


Richard Perham was distinguished for his contributions to our knowledge of the chemistry of proteins in multimeric assemblies. His novel methods of probing topography provided the chemical counterpart to X-ray diffraction studies and have been instrumental in providing an understanding of secondary forces, in particular of ionic interactions, in the structure, activity and self-assembly of multimeric enzymes and of tobacco mosaic virus. His work on the pyruvate dehydrogenase multienzyme complex opened up the precise chemical study of such enzymes and uncovered a remarkable system of active-site-coupling that can provide a new mechanism of rate enhancement in a multimeric enzyme.

Professor Richard Perham FRS died on 14 February 2015.

Biographical Memoir

Interest and expertise

Subject groups

  • Biochemistry and molecular cell biology
    • Molecular immunology
  • Other
    • Science policy, History of science
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