Professor Richard Perham FMedSci FRS
Richard Perham was distinguished for his contributions to our knowledge of the chemistry of proteins in multimeric assemblies. His novel methods of probing topography provided the chemical counterpart to X-ray diffraction studies and have been instrumental in providing an understanding of secondary forces, in particular of ionic interactions, in the structure, activity and self-assembly of multimeric enzymes and of tobacco mosaic virus. His work on the pyruvate dehydrogenase multienzyme complex opened up the precise chemical study of such enzymes and uncovered a remarkable system of active-site-coupling that can provide a new mechanism of rate enhancement in a multimeric enzyme.
Professor Richard Perham FRS died on 14 February 2015.
Interest and expertise
- Biochemistry and molecular cell biology
- Science policy, History of science