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Research Fellows Directory

Saverio Brogna

Dr Saverio Brogna

Research Fellow


University of Birmingham

Research summary

My research is about investigating basic mechanisms of gene expression - the process that leads from gene to active protein. The basic of these reactions are conserved in all eukaryotes (organisms made of cells with a nucleus), from unicellular organisms like yeast to human cells. Over the years there has been enormous progress in understanding eukaryotic gene expression, but the knowledge is limited by fact that, for convenience and tradition, the various processes have been studied as separate biochemical reactions. However, recent findings suggest that in the cell the different steps of gene expression are in fact coupled. I study the interconnections between these processes in two powerful model organisms: fission yeast and the fruit fly Drosophila.

Although, I don’t directly work with human cells, my research is about basic aspects of gene expression that are universally conserved. It is clear that true knowledge requires understanding the basic mechanisms of how genes work; therefore, I believe that in the long term my research it shall also provide insights into the molecular mechanisms involved in the pathogenesis of human diseases and their possible treatment. Much progress in medicine comes from discoveries in basic research, which was not initially aimed at investigating any particular disease.

Interests and expertise (Subject groups)

Grants awarded

Investigation of the molecular links between translation and pre-mRNA processing

Scheme: University Research Fellowship

Dates: Oct 2004 - Mar 2013

Value: £659,977.47

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