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Research Fellows Directory

Sheila Wang

Dr Sheila Wang B.Sc., M.Sc.,Ph.D.

Research Fellow

Organisation

University of Oxford

Research summary

My present research, which is in the field of Biological Chemistry, advances our understanding of important cellular processes by characterizing large protein complexes using ion mobility mass spectrometry, a technology used to characterize the shape and size of biomolecules. The potential of mass spectrometry for determining the architectures of protein-DNA complexes was highlighted in my first paper with the Robinson Lab published this year (Wang et al. J. Am. Chem Soc., 2010). Our current manuscript (in preparation) investigates the gas-phase structures of membrane proteins; membrane proteins constitute approximately 30% of the human genome and perform a wide range of critical functions including respiration, signal transduction and molecular transport. Consequently at least 50% of all drug targets are membrane proteins. However membrane proteins are notoriously difficult to study. Therefore, the ability to monitor native-like channels or transporters using mass spectrometry represents a significant advance in the field of membrane proteins. Besides the intrinsic academic interest, the development of new approaches to tackling the membrane protein structure problem is also clearly relevant to drug design and human health.

Interests and expertise (Subject groups)

Grants awarded

Elucidating the Structure of an Inhibitor-Bound Proteasome Complex by Mass Spectrometry

Scheme: Newton International Fellowships

Dates: May 2009 - May 2011

Value: £100,080

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