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Research Fellows Directory

Sneha Bansode

Ms Sneha Bansode

Research Fellow

Organisation

University of Cambridge

Research summary

Advanced glycation end products (AGEs) are an important factor in ageing and age related chronic disorders. AGEs majorly affect long lived proteins such as collagen by covalent modifications. Collagen makes up around 90 percent of bone extracellular matrix and interaction of collagen with its receptor on bone cells i.e. integrins, plays a vital role in the development of bone. High resolution mass spectrometry will be used for analysis of collagen glycation followed by advanced NMR spectroscopy to elucidate the atomic structure of glycated collagen and its integrin binding sites. Collagen-integrin interaction also have a key role in the bone morphogenic proteins (BMPs) signaling which is essential for formation of bone. Thus, we will also explore the effect of glycated collagen on this pathway and bone cell differentiation. The combination of advanced biophysical and cell biology methods will give detailed insights about the effect of AGE modification of collagen on bone development and repair.

Interests and expertise (Subject groups)

Grants awarded

Molecular investigation of AGE modified collagen-integrin interaction and related cellular responses

Scheme: Newton International Fellowships

Dates: Mar 2016 - Feb 2018

Value: £101,000