Research Fellows Directory
Tsan Yuk Lam
Dr Tsan Yuk Lam
University of Oxford
I study the evolution and epidemiology of the influenza virus as a unified dynamic process. Being one of the most dangerous pathogens in the world, human influenza virus evolves very rapidly through time, allowing it to evade the immunity we acquire from previous infections or from vaccination when sufficient mutations have accumulated. Conventionally, geneticists study influenza mutations that confer immune escape and drug resistance, while epidemiologists investigate the speed, extent and pattern of the virus spreading in human populations. Evidence has shown that the evolutionary and epidemiological behaviors of influenza viruses are inextricably linked. I am studying both aspects using a range of viral genomic and epidemiological data collected by long-term global surveillance. Ultimately, my research aims to develop a unified model of the behavior of human influenza virus, and to predict the emergence of antigenically-novel variants in the future.
Interests and expertise (Subject groups)