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Research Fellow

Interests and expertise (Subject groups)

Grants awarded

Epigenetic regulation of antibiotic production in Streptomyces

Scheme: University Research Fellowship

Organisation: John Innes Centre

Dates: Jan 2016-Dec 2020

Value: £561,272.53

Summary: Our laboratory is interested in understanding how bacterial chromosomes are organized spatially in vivo and how these organizations impact a range of cellular processes, including DNA replication, DNA segregation, DNA repair, homologous recombination, and horizontal gene transfer. Recent work, driven in part by technological advances (for example, Hi-C) has begun to reveal the general principles of chromosome organization in bacteria. The emerging picture is that bacterial chromosomes are structured at multiple length-scales by various DNA-binding proteins and physical forces. Although there has been tremendous progress, there are gaps that remain in understanding chromosome organization and its biological functions. We aim to gain deeper understanding through investigating: 1) The global organization of bacterial chromosomes under different stress conditions/developmental stages 2) Protein-based systems that anchor specific DNA regions 3) Chromosomal domains/supercoiling domains and their influence on gene expression and regulation 4) Nucleoid-associated proteins with DNA bridging, wrapping, or bending activities and their contribution to the organization of the chromosome and regulation of gene expression Our work often employs genome-wide methods such as chromosome conformation capture in conjunction with deep sequencing (Hi-C) and other next-generation sequencing techniques to map the 3D structure of the chromosome and to correlate this structure with its biological functions. We also use traditional genetics, biochemistry and cell biology to delve into particular biological question to gain deeper understanding. Currently we employ Caulobacter crescentus as an experimental model for our studies but we are open to explore other bacterial system (in particularly, Streptomyces) should they be more fitted for a particular biological question.

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