Research Fellows Directory
Dr Wenlin Li
University College London
Chemical approaches utilizing small molecules to steer biological systems towards specific outcomes have been proven to be especially useful in studying stem cell biology. The current focus of my research is to investigate the neural ectoderm and endoderm lineage specification of human pluripotent stem cells (hPSCs) through the chemical approaches. As it is practically difficult to non-invasively isolate most types of adult stem cells from specific tissues, we especially interested in capturing and maintaining multipotent stem cells or lineage progenitors from hPSCs through high-content chemical screening. The current project is in collaboration with Dr Huiliang Li at the University College London to induce rapid and efficient production of oligodendrocyte precursors from hPSCs with a view to developing innovative stem cell based therapies for white matter diseases. In addition, related work also aims to identify small molecular compounds with potential to induce the regeneration of endogenous oligodendrocyte precursors.
Interests and expertise (Subject groups)