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Research Fellows Directory

Ying Xu

Professor Ying Xu

Research Fellow


Wellcome Trust Sanger Institute

Research summary

Circadian rhythms are endogenous rhythms in physiology or behaviour with a period length near 24 hours in all genetically studied organisms. In most cases, these rhythms are generated by endogenous processes referred to as circadian oscillators. These oscillators provide temporal structure to an organism’s physiological processes. My group is using cellular, molecular, genetic, evolutional and behavioural approaches to more fully understand the circadian system, with a focus on identifying linkers between circadian system and peripheral tissues such as metabolism, sleep and understanding the molecular mechanism of the circadian clock. Another major project is on the basis of collaboration and confidence between both groups, my group at soochow University in china and Dr Willian Skarnes at the Wellcome Trust Sanger Institute are developing a Shared UK-Chinese Resource for Genetically Modified Mouse and Human ES Repository. Wellcome Trust Sanger Institute released EUCOMM ES cell resources to Soochow University on 28 March, 2014, and granted CAM-SU GRC the exclusive right including distributing the targeted ES cells stock to Asia-pacific scientific community followed by EUCOMM repository and distribution policy. As a result, Soochow University become the fourth EUCOMM ES distribute center after German, USA and Sanger Institute. A partnered resource would directly enhance the parallel efforts of the EUCOUMM in UK and CAM-SU GRC in China to create, phenotype, analyze, and distribute new and relevant Resource, and facilitate rapid and cost-effective access to available mouse models of human disease by both UK and Chinese investigators, bringing value to the research community in the availability of relevant disease models for health research and drug discovery.

Interests and expertise (Subject groups)

Grants awarded

Development of a Shared UK-Chinese Repository for Genetically Modified Mouse ES Cells

Scheme: Newton Advanced Fellowship

Dates: Mar 2016 - Feb 2018

Value: £74,000