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Zamin Iqbal

Dr Zamin Iqbal

Dr Zamin Iqbal

Research Fellow

Interests and expertise (Subject groups)

Grants awarded

Statistical methods for analyzing complex genomic variation in human pathogens.

Scheme: Sir Henry Dale Fellowship

Organisation: University of Oxford

Dates: Jan 2014-Jan 2019

Value: £769,446

Summary: My research focuses on pathogens - organisms that live in or on humans and in some way harm them. Pathogens evolve rapidly, in three ways: 1. Normal inheritance: A parasite inherits its DNA from its parents, and sometimes also gets some mutations to its DNA. 2. Horizontal transfer of genes: Bacteria can have extensive optional-extra sections of their DNA, which can give them extra powers (e.g. resistance to antibiotics), and they swap these back and forth between individuals. 3. Hyper-evo lving genes: The human immune system indirectly recognizes some parasite genes. To avoid being killed, the parasite needs a way of accelerating the evolution of these genes. Some do this by having many slightly different copies of these genes, and cut-and-pasting DNA between them. They also switch rapidly between which copy is turned on, to confuse the immune-system further. This mechanism is of critical importance for malaria. Standard approaches to studying pathogen DNA are very good at han dling normal inheritance, rathe

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