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Catalysis by enzymes - beyond the transition state theory paradigm

Event

Starts:

November
142005

09:00

Ends:

November
152005

18:00

Location

The Royal Society, London, 6-9 Carlton House Terrace, London, SW1Y 5AG

Overview

By Professor Nigel Scrutton, Professor Les Dutton FRS, Dr Andrew Munro and Dr Mike Sutcliffe

Enzymes are catalysts that can achieve substantial rate enhancements over the uncatalysed reaction. The physical basis of this catalysis remains controversial. Theoretical frameworks, computational simulations and experimental observations are emerging that might explain their catalytic potency. Amongst others, potential roles for electrostatics, quantum tunnelling, coupled protein motions, low-barrier hydrogen bonds and near attack conformers will be discussed.

Catalysis by enzymes - beyond the transition state theory paradigm

Discussion meeting organised by Professor Nigel Scrutton, Professor Les Dutton FRS, Dr Andrew Munro and Dr Mike Sutcliffe

The Royal Society, London 6-9 Carlton House Terrace London SW1Y 5AG UK