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Unstructured proteins: cellular complexity and human diseases

Prize lecture

Event video


18:30 - 19:30


The Royal Society, London, 6-9 Carlton House Terrace, London, SW1Y 5AG


Francis Crick Prize Lecture 2016 given by Dr Madan Babu Mohan

Network rewiring by cancer fusion gene. © MRC Lab of Molecular Biology, adapted by Paul Margiotta.

If DNA is the blueprint of life, proteins are the building blocks. Research over the last century has shown that the shapes adopted by proteins determine their functions. Mutations that affect their shapes cause human diseases. However in recent decades, scientists have discovered that a large number of proteins do not adopt defined shapes. Nevertheless, these unstructured proteins perform functions that are critical for the survival of organisms.

The audience joined Dr Mohan in discovering how unstructured proteins perform their functions, contribute to cellular complexity and cause human diseases including cancer and neurodegeneration.

This lecture has passed, please view the video link above to watch the lecture.

The award

The Francis Crick Lecture is given annually in any field in the biological sciences. Preference is given to genetics, molecular biology and neurobiology, the general areas in which Francis Crick worked, and to fundamental theoretical work, which was the hallmark of Crick’s science.

Dr Madan Babu Mohan was awarded the 2016 Francis Crick lecture for his major and widespread contributions to computational biology.

For all enquiries, please contact

Unstructured proteins: cellular complexity and human diseases The Royal Society, London 6-9 Carlton House Terrace London SW1Y 5AG UK