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Investigating the structure of molecules inside cells

Public event

Event video

June
212018

18:30 - 19:30

Location

The Royal Society, London, 6-9 Carlton House Terrace, London, SW1Y 5AG

Overview

International Lecture given by Professor Wolfgang Baumeister.

The molecular sociology of the Hela cell nuclear periphery as revealed by cryo-electron tomography. Mahamid J et al. 2016 Visualizing the molecular sociology at the HeLa cell nuclear periphery. Science 351, 969-972

In the past, macromolecular structures have been characterized by methods requiring their isolation and purification. When taken out of their functional context, information about their interactions within the cellular environment is lost. However, it is the interaction between the many molecular species inhabiting cells which underlies cellular functions. Many of them exist only fleetingly or, when integrated in supramolecular complexes, these may be rooted so deeply in cells that they cannot be isolated without affecting their structural integrity. 

Professor Baumeister discussed a method, cryo-electrontomography, that has the unique potential to study the ‘molecular sociology’ of cells, combining the best structural preservation with 3D high resolution imaging.

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Investigating the structure of molecules inside cells

International Lecture given by Professor Wolfgang Baumeister.

The Royal Society, London 6-9 Carlton House Terrace London SW1Y 5AG UK
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