Skip to content
What's on

Developing new approaches for the single cell manipulations and experimentation

Scientific meeting

Location

Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell, Buckinghamshire, MK16 9JJ

Overview

Satellite meeting organised by Professor Thomas Richards, Dr Ramon Massana and Professor Neil Hall

Monolayer of bacteroidetes cells (false coloured blue) on the surface of the parabasalian protist Barbulonympha. © K Carpenter and P Keeling (University of British Columbia).

Single cell approaches are changing how we study many biological problems. This meeting will bring together biophysicists, molecular biologists and microbial ecologists who are using these technologies to understand the natural world. The aim of this satellite meeting is to report progress, identify areas for synergy and lay down the foundations for further developing this interdisciplinary science.

The schedule of talks and speaker biographies are below. Speaker abstracts will be available closer to the meeting. Recorded audio of the presentations will be available on this page after the meeting has taken place.  

Poster session

There will be a poster session at 16:15 on Wednesday 12 December. If you would like to apply to present a poster please submit your proposed title, abstract (not more than 200 words and in third person), author list, name of the proposed presenter and institution to the Scientific Programmes team with the subject heading "Single cell new approaches: poster abstract" no later than Monday 22 October 2018. Please note that places are limited and posters are selected at the scientific organiser's discretion. Poster abstracts will only be considered if the presenter is registered to attend the meeting.

Attending the event

This is a residential conference, which allows for increased discussion and networking.

  • Free to attend
  • Limited places, advanced registration is essential (request an invitation)
  • Catering and accommodation available to purchase during registration

Enquires: Contact the Scientific Programmes team.

Event organisers

Select an organiser for more information

Schedule of talks

12 December

09:00-12:30

Session 1

5 talks Show detail Hide detail

Chairs

Dr Ramon Massana Institute of Marine Sciences, CSIC, Spain

09:05-09:30 Single cell approaches to study microbe-microbe interactions

Dr Stefan Bertilsson, Uppsala University, Sweden

Abstract

Microbial interactions are central in governing and controlling microbial community composition and function. Yet the bulk approaches normally applied are likely to overlook these interactions that are typically manifested at the microscopic scale. Applying single cell genome sequencing approaches can to begin with help us describe the metabolic capabilities of the largely unculturable natural microbial communities, and with sufficient coverage also identify auxotrophies and metabolic dependencies. Furthermore, when single cell genomics methods are also applied to physically associated cells, we can begin to infer functional interactions from such linkages and combine this information with genome-encoded functional potential. Here Stefan will discuss and present preliminary data highlighting both challenges and opportunities in these and related approaches and provide my personal view on ways to better understand microbe-microbe interactions in the uncultured majority.

Show speakers

09:45-10:15

Dr Iñaki Ruiz-Trillo, Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Spain

Show speakers

10:30-11:00 Coffee

11:00-11:30

Dr Gwenaël Piganeau, CNRS, Integrative Biology of Marine Organisms Lab, France

Show speakers

11:45-12:15

Dr Susanne Wilken, University of Amsterdam, The Netherlands

Show speakers

12:30-13:30

Lunch

13:30-18:00

Session 2

5 talks Show detail Hide detail

13:30-14:00

14:15-14:45

15:00-15:30 Tea

15:30-16:00 Understanding microbial interactions with eukaryotes at a single cell level

Dr Alistair Darby, University of Liverpool, UK

Show speakers

16:15-18:00 Poster session

13 December

09:00-12:30

Session 3

5 talks Show detail Hide detail

Chairs

Professor Neil Hall, Earlham Institute, UK

09:00-09:30

Dr Vicente Fernandez, ETH Zürich, Switzerland

Show speakers

09:45-10:15

Dr Purificacion Lopez-Garcia, CNRS - Université Paris-Sud, France

Show speakers

10:30-11:00 Coffee

11:00-11:30

11:45-12:15 Single cell approaches for studying marine archaea

Dr Alyson Santoro, University of California, Santa Barbara, USA

Show speakers

12:30-13:30

Lunch

13:30-17:00

Session 4

5 talks Show detail Hide detail

Chairs

Professor Tom Richards, University of Exeter, UK

13:30-14:00

Dr Christopher Vollmers, University of California Santa Cruz, USA

Show speakers

14:15-14:45 Early metazoan cell type diversity and regulation by single-cell RNA-seq analysis

Dr Arnau Sebé-Pedrós, Weizmann Institute of Science, Israel

Abstract

A fundamental characteristic of animals is their ability to form large cell populations that are capable of cooperating through interaction between different archetypical functional programs, which are sometimes called cell types. The deployment and maintenance of these cell type-specific transcriptional programs is coordinated by transcription factor regulatory networks. However, the phylogenetic relationships and evolutionary dynamics underlying cell type hierarchies and their regulation are poorly understood. To gain insights into this question Arnau’s group profiled thousands of single-cell transcriptomes in the cnidarian Nematostella vectensis and other early-branching animals. The resulting whole-organism cell type classification atlases reveal an unanticipated high diversity of cell types in some of these species, particularly neuronal types. Moreover, the group identifies the gene modules specific to these cell behaviours, as well as the master transcription factors regulating them at different levels of the cell type hierarchy. These results provide the first glimpses to early-multicellular cell type complexity and the regulatory principles that orchestrate it.

Show speakers

15:00-15:30 Tea

15:30-16:00 Single cell multi-omics: multiple measurements from single cells

Dr Iain Macaulay, Earlham Institute, UK

Abstract

The ability to analyse the genomes, epigenomes and transcriptomes of individual cells has offered a new way in which to explore cellular heterogeneity in a diverse array of living systems. The Macaulay group has focussed on the development of technologies that enable us to explore, in parallel, multiple omic parameters of single cells – enabling combined gene expression and genome sequencing from the same cell. Another major focus of the group's work in this area is the understanding of alternative splicing in individual cells using long-read sequencing. In this talk Iain Macaulay will give an overview of the group’s approaches, how they aim to apply them in a wide array of applications across mammalian, plant and microbial biology.

Show speakers

16:15-17:00 Panel discussion/overview

Related events

Developing new approaches for the single cell manipulations and experimentation

Satellite meeting organised by Professor Thomas Richards, Dr Ramon Massana and Professor Neil Hall

Kavli Royal Society Centre, Chicheley Hall Newport Pagnell Buckinghamshire MK16 9JJ
Was this page useful?
Thank you for your feedback
Thank you for your feedback. Please help us improve this page by taking our short survey.