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Overview

Scientific discussion meeting organised by Professor Peter Cullen, Professor Peter St George-Hyslop FRS, Professor Scott Small and Dr Henne Holstege.

Abnormalities in the endosomal network are a signature feature of Alzheimer's disease, Parkinson's disease and numerous other neurological disorders. In bringing together world leading researchers from a range of disciplines, this meeting seeks to discuss the latest advances in this rapidly moving field and foster collaborative efforts to enhance the rate of discovery in this medically important research field.

The schedule of talks and speaker biographies are available below. Speaker abstracts will be available closer to the meeting date.

Selected presentations

There is the opportunity to give a short presentation at the meeting. If you would like to apply to give a presentation please submit your proposed title, abstract (not more than 200 words and in third person), author list, name of the proposed presenter and institution to the Scientific Programmes team no later than Friday 21 October 2022. Please note that places are limited and presentations are selected at the scientific organisers' discretion.

Poster session

There will be a poster session on Monday 21 November. If you would like to apply to present a poster please submit your proposed title, abstract (not more than 200 words and in third person), author list, name of the proposed presenter and institution to the Scientific Programmes team no later than Friday 21 October 2022. Please include the text 'Poster abstract submission' in the email subject line. Please note that places are limited and posters are selected at the scientific organisers' discretion. Poster abstracts will only be considered if the presenter has registered to attend the meeting (in person or online).

Attending this event

This meeting is intended for researchers in relevant fields.

  • Free to attend
  • Both in person and online attendance will be available
  • Limited places, advance registration essential

Enquiries: contact the Scientific Programmes team

Organisers

Schedule

09:00-09:05
Welcome
09:05-09:25
Genetic risk, consequences, and rescue of rab5-endosome dysfunction in Alzheimer’s Disease

Speakers

09:25-09:35
Discussion
09:35-09:55
Talk title tbc

Speakers

09:55-10:05
Discussion
10:05-10:25
Speaker tbc
10:25-10:35
Discussion
10:35-11:00
Coffee
11:00-11:10
Selected presentation
11:10-11:15
Discussion
11:15-11:25
Selected presentation
11:25-11:30
Discussion
11:30-11:50
The trans-entorhinal cortex differential relies on a distinct retromer core dedicated to endosomal recycling

Speakers

11:50-12:00
Discussion
12:00-12:20
Speaker tbc
12:20-12:30
Discussion

Chair

13:30-13:50
Endolysosomal dysfunction in Alzheimer’s disease pathogenesis

Speakers

13:50-14:00
Discussion
14:00-14:20
Cell-type specific actions of the SORL1-retromer axis in human neural cells

Speakers

14:20-14:30
Discussion
14:30-14:40
Selected presentation
14:40-14:45
Discussion
14:45-14:55
Selected presentation
14:55-15:00
Discussion
15:00-15:20
Understanding pathogenic variants of the endosomal recycling receptor SORL1 in Alzheimer’s disease

Speakers

15:20-15:30
Discussion
15:30-16:00
Tea
16:00-16:20
Loss of NPC1 in microglia triggers pathology in other brain cells

Speakers

16:20-16:30
Discussion
16:30-16:50
Genetic variants in the SORL1 gene and consequences for Alzheimer’s Disease risk

Speakers

16:50-17:00
Discussion

Chair

09:00-09:20
Regulation and function of LRRK2 and its roles in Parkinson's

Speakers

09:20-09:30
Discussion
09:30-09:50
Exploring endocytic dysfunction in neurons and microglia in late onset Alzheimer’s disease

Speakers

09:50-10:00
Discussion
10:00-10:20
Understanding VPS35 and retromer dysfunction in Parkinson’s Disease

Speakers

10:20-10:30
Discussion
10:30-11:00
Coffee
11:00-11:10
Selected presentation
11:10-11:15
Discussion
11:15-11:25
Selected presentation
11:25-11:30
Discussion
11:30-11:50
Autophagy defects in the gut regulate systemic innate immune activation in a Drosophila model of glucocerebrosidase deficiency

Speakers

11:50-12:00
Discussion
12:00-12:20
Parkinson’s associated Leucine-Rich Repeat Kinase 2 is activated at lysosomes

Speakers

12:20-12:30
Discussion

Chair

13:30-13:50
VPS35 causal mutations in Parkinson’s disease

Speakers

13:50-14:00
Discussion
14:00-14:20
Talk title tbc

Speakers

14:20-14:30
Discussion
14:30-14:50
Speaker tbc
14:50-15:00
Discussion
15:00-15:10
Selected presentation
15:10-15:15
Discussion
15:15-15:25
Selected presentation
15:25-15:30
Discussion
15:30-16:00
Tea
16:00-17:00
Panel discussion

Speakers

Related Events

Online event

Understanding the endosomal network in neurodegeneration

09 - 12 November 2020