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Overview

The Third International Summit on Human Genome Editing will take place on 6-8 March 2023 at the Francis Crick Institute, London UK.

The Third International Summit on Human Genome Editing will take place on 6-8 March 2023 at the Francis Crick Institute, London UK.

Building on previous events held in Washington, DC (2015) and Hong Kong (2018), the London meeting will continue the global dialogue on somatic and germline human genome editing. Major themes for discussion include developments in clinical trials and genome editing tools such as CRISPR/Cas9, as well as social, ethical and accessibility considerations these scientific developments entail.

The three-day Summit is being organised by the Royal Society, the UK Academy of Medical Sciences, the US National Academies of Sciences and Medicine and The World Academy of Sciences. Find out more about the Summit’s Planning Committee, chaired by Professor Robin Lovell-Badge FMedSci FRS.

In preparation for the Summit, a three-part series of online events was held in 2022 (Looking Ahead to the Third Human Genome Editing Summit), which focused on scientific developments, equity and access, and governance of human genome editing. Presentations for all the speakers are available on the event page.

Further information about the Summit agenda will be released soon, and registration to attend the event in person and online is now open.

Schedule

09:30-10:00
Introduction and history of the summits

Speakers

Victor Dzau

United States National Academies of Sciences and Medicine

David Baltimore

The California Institute of Technology

10:00-10:25
Regulation in China following the 2018 clinical use of heritable human genome editing

Speakers

Joy Zhang

University of Kent

10:25-12:05
Hopes and fears for human genome editing

Speakers

Filippa Lentzos

King's College London

David Liu

Broad Institute, Harvard University & Howard Hughes Medical Institute

12:05-12:50
International equity for access to gene therapies

Speakers

Jantina De Vries

University of Cape Town

Natacha Salomé Lima

National Scientific and Technical Research Council (CONICET) & Universidad de Buenos Aires

Ping Yan

Dalian University of Technology

13:50-15:40
Sickle Cell Disease: a case study affecting millions

Speakers

Alexis Thompson

Children’s Hospital of Chicago in Chicago & Northwestern University

Ambroise Wonkam

SickleInAfrica & African Society of Human Genetics

Melissa Creary

University of Michigan

Arafa Salim Said

Sickle Cell Disease Patients Community of Tanzania

Gautam Dongre

National Alliance of Sickle Cell Organizations (NASCO) India

John Tisdale (tbc)

National Heart, Lung and Blood Institute, USA National Institute of Health

Dan Bauer

Boston Children's Hospital, Dana-Farber Cancer Institute & Harvard Medical School

Kofi Anie

London North West University Healthcare NHS Trust & Imperial College London

Daima Bukini

Muhimbili University of Health and Allied Sciences

08:30-09:30
Role of non-scientists in setting research agendas

Speakers

Mathieu Boudes

Montsouris Consilium

Bettina Ryll

Melanoma Patient Network Europe & European Commission

Alex Pearlman

Bioethicist & Journalist

Māui Hudson

University of Waikato

09:30-12:00
Clinical research involving somatic editing

Speakers

Rachel Haurwitz

Caribou Biosciences

Sonja Schrepfer

University of California San Francisco & Sana Biotechnology Inc

Amy Wagers

Harvard University

Mike McCune

Bill & Melinda Gates Foundation

Steve Pearson

Institute for Clinical and Economic Review

Joni L Rutter

National Center for Advancing Translational Sciences, USA National Institute of Health

13:00-15:30
Update of science and techniques of genome editing for therapeutic uses: current barriers to clinical applications and non-therapeutic uses

Speakers

Tippi Mackenzie

University of California, San Francisco

Fyodor Urnov

University of California, Berkeley

Yenew Kebede Tebeje

Africa Centres for Disease Control and Prevention (CDC)

Angelo Lombardo

San Raffaele-Telethon Institute for Gene Therapy & Vita-Salute San Raffaele University

16:00-17:30
Regulation and policy approaches to increase accessibility for somatic editing

Speakers

Piers Millett

iGEM Foundation, Biosecure & University of Oxford

Katherine Littler

World Health Organization

Kiran Musunuru

University of Pennsylvania

Sérgio Pena

Universidade Federal de Minas Gerais

09:00-09:45
The role of civil society and culture in fostering public engagement on the ethics of human genome editing

Speakers

Lluís Montoliu

ARRIGE & National Centre of Biotechnology (CNB-CSIC)

Sheila Jasanoff

Global Observatory & Harvard University

Sarojini Nadimpally

SAMA Resource Group for Women and Health

Simon Niemeyer

Global Citizens’ Assembly on Genome Editing & University of Canberra

09:45-10:30
Reproductive options and genetic lineage in different cultures

Speakers

Ephrat Levy-Lahad

Shaare Zedek Medical Center

César Palacios-González

University of Oxford

Tina Rulli

University of California, Davis

11:00-12:40
Update of science and techniques of heritable editing of gametes

Speakers

Amander Clark

University of California, Los Angeles

Katsuhiko Hayashi (tbc)

Kyushu University

Kyle Orwig

University of Pittsburgh

Mitinori Saitou

Kyoto University

13:40-15:40
Update on science and techniques for heritable editing of embryos

Speakers

Dieter Egli

Columbia University Irving Medical Center

Shoukhrat Mitalipov

Oregon Health and Science University

Kathy Niakan

Francis Crick Institute & University of Cambridge

Yuyu Niu

State Key Laboratory of Primate Biomedical Research & Kunming University of Science and Technology

Sunney Xie

Peking University

16:10-17:00
How to enforce research policies and ethical principles for human genome editing

Speakers

María de Jesús Medina Arellano

National Autonomous University of Mexico

Yaojin Peng

Chinese Academy of Sciences

Leigh Turner

University of California, Irvine

17:00-18:00
Concluding remarks from the Planning Committee

Speakers