My research focuses on how new blood vessel formation is regulated. I have two main projects. The first investigates why new vessels are malformed and fragile in the inherited disorder Hereditary Hemorrhagic Telangiectasia (HHT), and to use this knowledge to help develop new therapies to treat HHT patients. A second major project is to promote new blood vessel formation in the heart following myocardial infarction in order to enhance heart repair.
I originally trained in the field of DNA repair, gaining a lectureship in 1983, and then took a seven-year career break when my children were young. After that, a career re-entry fellowship helped me to re-establish a research career, in what was to me a completely new field of cardiovascular genetics. My career break gave me an extra appreciation of how much I love my work, and my family have always been very supportive. Also, Stephen, my youngest, has become an exceptionally good cook, partly because he got fed up waiting for me to make his dinner!