T cells are white blood cells that are important for clearing infection and cancer. One of the major challenges in understanding T cells (and more broadly in molecular immunology) is no longer to identify new molecules but to understand the interaction networks that the identified molecules form. We are directly addressing this challenge by using quantitative molecular and cellular experiments combined with mechanistic and phenotypic models to understand the complex signaling networks underlying immune cell activation. We aim to exploit this knowledge for the benefit of human health.
We try to take a modular approach so that one of us is primarily responsible for the little squeaker while the other gets to either work or have adult time. Importantly, we try not to be too hard on ourselves and resolved to muddle our way through child rearing rather then strive for perfection.