Targeting the human kinome: cancer drug discovery

GlaxoSmithKline Prize and Lecture by Dr Nicholas Lydon FRS

Dr Nicholas Lydon is the founder of Granite Biopharma LLC

Event details

Nicholas Lydon played a decisive role in the development of Gleevec (Imatinib), a drug that has saved the lives of thousands of patients with chronic myelogenous leukaemia (CML) and gastrointestinal stromal tumours (GIST). In this prize lecture he discusses how the discovery of the Philadelphia chromosome provided the first example of a link between cancer and a recurrent genetic abnormality. This chromosomal translocation, which results in activation of the Abl protein kinase, represents the “driver” mutation in CML. The discovery and development of Imatinib provides an early example of the potential of targeted therapy in genetically defined patient populations. Such personalized targeted therapies, if highly selective, may offer advantages such as enhanced efficacy and reduced toxicity, and could be used in combination with other agents that independent target other cancer cell dependencies.

The Royal Society GlaxoSmithKline Prize and Lecture is awarded biennially for original contributions to medical and veterinary sciences. Dr Nicholas Lydon FRS was awarded the prize for his development of the drug imatinib, a targeted tyrosine kinase inhibitor that has transformed the treatment of chronic myelogenous leukaemia (CML) and is a paradigm for cancer drug discovery.

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Targeting the human kinome: cancer drug discovery 6-9 Carlton House Terrace London SW1Y 5AG UK

Events coming up

  • The interaction of fire and mankind 14 September 2015 at The Royal Society, London Scientific discussion meeting organised by Professor Andrew Scott, Professor William Chaloner FRS, Professor Claire Belcher and Dr Chris Roos
  • The interaction of fire and mankind - further discussion 16 September 2015 at The Royal Society at Chicheley Hall, home of the Kavli Royal Society International Centre, Buckinghamshire Scientific discussion meeting organised by Professor Andrew Scott, Professor William Chaloner FRS, Dr Claire Belcher and Professor Chris Roos
  • Open House Weekend 2015 19 September 2015 at The Royal Society, London The Royal Society's building will be open to the public on Saturday 19 and Sunday 20 September 2015.

For more events please see the events diary.