Semen takes control of females’ genes

12 September 2012

Title:Sex peptide of D. melanogaster males is a global regulator of reproductive processes in females

Authors:A. Gioti, S. Wigby, B. Wertheim, E. Schuster, P. Martinez, C. J. Pennington, L. Partridge and T. Chapman

Journal:Proceedings of the Royal Society B

Chapman

Sex can trigger remarkable female responses including altered fertility, immunity, libido, eating and sleep patterns - by the activation of diverse sets of genes, according to research published in Proceedings of the Royal Society B today.

Researchers at the University of East Anglia studied how female Drosophila melanogaster - or fruit flies – respond to mating.

They discovered that a single protein found in semen generates a wide range of responses in many genes in females, which become apparent at different times and in different parts of the female’s body following mating. The findings could in principle be akin to responses in many animals, including humans.

Lead researcher Prof Tracey Chapman, from UEA’s school of Biological Sciences, said: “It’s already known that seminal fluid proteins transferred from males during mating cause remarkable effects in females – including altered egg laying, feeding, immunity, sleep patterns, water balance and sexual receptivity.

“We tested here the effects of one enigmatic seminal fluid protein, known as the ‘sex peptide’, and found it to change the expression of a remarkable array of many genes in females – both across time and in different parts of the body.

“There were significant alterations to genes linked to egg development, early embryogenesis, immunity, nutrient sensing, behaviour and, unexpectedly, phototransduction – or the pathways by which they see.

“It showed that the semen protein is a ‘master regulator’ – which ultimately means that males effectively have a direct and global influence on the behaviour and reproductive system of the female. Such effects may well occur across many species.

“An additional and intriguing twist is that the effects of semen proteins can favour the interests of males whilst generating costs in females, resulting in sexual conflict.

“For example, there can be a tug-of-war, where males employ semen proteins to ensure that females make a large investment in the current brood – even if that doesn’t suit the longer term interests of females”.

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