Scheme: Newton Advanced Fellowship
Organisation: University of Edinburgh
Dates: Mar 2015-Mar 2017
Summary: My research is focused on the preparation of nitric oxide (NO)-releasing nanoparticles and their effects on human skin. Human skin contains stores of nitrogen oxides, which can be mobilised to release NO to the systemic circulation on UV irradiation with beneficial effects on cardiovascular health. The mechanism of NO storage and flux remains unclear, and depletion of NO stores may occur following prolonged irradiation with reduced clinical benefit. I have been developing a range of NO donors based on metallic or polymeric nanoparticles coated or loaded with NO or nitrosothiols. The aim of this project is to measure NO loading of human skin and determine the photochemistry of this storage form. Using ex vivo human skin discarded from operations and NO fluorochrome and
chemiluminescence based assays, the project will study NO release mechanisms on UV irradiation and then measure how NO donors can augment natural skin NO stores. Moreover, the pharmacokinetic behaviour of locally developed NO donors as possible therapeutic agents will be evaluated.