Research Fellows Directory
Professor Andrea Balan
University of Cambridge
Our group is focused on the study of ATP Binding Cassete transporters and proteins of biotechnological importance. The main aspects of the research are: (i) The study of ATP-Binding Cassete transporters and their importance for bacterial infection, pathogenesis and drug resistance. As a model we use the phytopathogenic bacteria Xanthomonas citri, responsible for the citrus canker disease, and the Mycobacterium tuberculosis. We use spectroscopic assays, molecular modeling, molecular dynamics simulations and crystallography for the structural characterization and construction of mutants for functional analyses; (ii) Enzymes of biotechnological importance. We are interested in the structural studies of lipases and esterases isolated from oil contaminated soils. We use metagenomic to isolate the enzymes, biophisical methods for functional characterization and crystallization for determination of their structures; (iii) Structural characterization and validation of drug targets for Mycobacterium tuberculosis. We are working on the structural characterization of ABC transporters from M. tuberculosis involved with infection and drug resistance for the development of strategies of bacterium control.
Interests and expertise (Subject groups)