Research Fellows Directory
Mr Antonio Laezza
University of Warwick
Carbohydrates are involved in many biological events from infection, to wound healing, to the recognition of ‘self’.
Glycosaminoglycan (GAGs) belong to this class. They are polysaccharides which are clinically used but are not ‘pure’ compounds and have huge structural variability.
By the combination of chemical and enzymatic synthetic methods in a robotic platform, the normal limiting step of glycan synthesis will be overcome, enabling access to large libraries of structurally diverse GAGs mimetic materials. Semi-synthetic GAGs could address many unmet medical needs, but the methods to access them are limited and do not generate true structural diversity. These ‘synth-GAGs’ obtained under software control will be screened for function, in particular for manipulation of stem cell fate, moving then from chemo-enzymatic synthesis to biology, as well as, from medicine to material science.
Interests and expertise (Subject groups)