Brian Moore is distinguished for his research on the psychophysics of auditory perception in normal and hearing-impaired listeners. His research has led to new insights into the mechanisms of pitch perception, frequency selectivity and intensity coding and has had direct impact on the design of hearing aids and on the control of environmental noise pollution.

He showed that pitch, including that of speech, is partially coded in terms of neural phase-locking to the individual cycles of the stimulus waveform for frequencies below 4–5 kilohertz. He developed new techniques for estimating the characteristics of auditory filters and their use in predicting when one sound will mask another. He also developed models that can accurately predict the loudness of complex sounds as perceived by both normal-hearing and hearing-impaired people.

Brian has received the silver and gold medals of the Acoustical Society of America, the Award of Merit from the Association for Research in Otolaryngology, the International Award in Hearing from the American Academy of Audiology, and the Hugh Knowles Prize for Distinguished Achievement from Northwestern University.