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Fellows Directory

Brigid Hogan

Brigid Hogan

Professor Brigid Hogan FRS

Fellow


Elected: 2001

Biography

Brigid Hogan pioneered techniques for exploring the molecular and genetic basis of embryonic development and patterning in the mouse. Using transgenic and gene-targeted mouse lines, tissue transplantation, and in vitro culture techniques, her lab identified key signalling pathways that direct the development of several organs systems, including the eye, kidney, germ cells and lung, from undifferentiated progenitor cell populations.

More recently, her lab has focused on the mechanisms controlling the process of ‘branching morphogenesis’, by which the epithelial and mesenchymal tissues of the simple lung primordia give rise to the tree-like airways and terminal alveoli of the neonatal lung. Her lab has also identified stem cells present in the adult lung and studies how they repair local tissue after damage and how defective repair promotes fibrosis.

Brigid is a leading advocate of the use of embryonic stem cells in research and helped to prepare the prescient and influential 1994 report of the US National Institutes of Health Human Embryo Research Panel.

Interest and expertise

Subject groups

  • Microbiology, immunology and developmental biology
    • Developmental biology
  • Other
    • Public understanding of science
  • Biochemistry and molecular cell biology
    • Cell biology (incl molecular cell biology)

Keywords

Adult stem cells, Embryonic stem cells, Organogenesis, Lung development, Tissue repair, Branching morphogenesis

Awards

  • Croonian Medal and Lecture

    For pioneering contributions that have transformed understanding of cell specification, organogenesis and morphogenesis in mammalian development.

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